+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The impact of comorbidities on outcomes for elderly women treated with breast-conservation treatment for early-stage breast cancer



The impact of comorbidities on outcomes for elderly women treated with breast-conservation treatment for early-stage breast cancer



International Journal of Radiation Oncology, Biology, Physics 70(5): 1453-1459



Breast cancer incidence increases with age and is a major cause of morbidity and mortality in elderly women, but is not well studied in this population. Comorbidities often impact on the management of breast cancer in elderly women. From 1979 to 2002, a total of 238 women aged 70 years and older with Stage I or II invasive carcinoma of the breast underwent breast-conservation therapy. Outcomes were compared by age groups and comorbidities. Median age at presentation was 74 years (range, 70-89 years). Age distribution was 122 women (51%) aged 70-74 years, 71 women (30%) aged 75-79 years, and 45 women (19%) aged 80 years or older. Median follow-up was 6.2 years. On outcomes analysis by age groups, 10-year cause-specific survival rates for women aged 70-74, 75-79, and 80 years or older were 74%, 81%, and 82%, respectively (p = 0.87). Intercurrent deaths at 10 years were significantly higher in older patients: 20% in those aged 70-74 years, 36% in those aged 75-79 years, and 53% in those 80 years and older (p = 0.0005). Comorbidities were not significantly more common in the older age groups and did not correlate with cause-specific survival adjusted for age. Higher comorbidity scores were associated with intercurrent death. Older age itself is not a contraindication to standard breast-conservation therapy, including irradiation. Women of any age with low to moderate comorbidity indices should be offered standard breast-conservation treatment if otherwise clinically eligible.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 021940734

Download citation: RISBibTeXText

PMID: 17980504

DOI: 10.1016/j.ijrobp.2007.08.059


Related references

Impact of Her-2 Neu overexpression on outcome of elderly women treated with wide local excision and breast irradiation for early stage breast cancer: an exploratory analysis. American Journal of Clinical Oncology 29(1): 71-79, 2006

Long-term clinical and cosmetic outcomes after breast conservation treatment for women with early-stage breast carcinoma according to the type of breast boost. International Journal of Radiation Oncology, Biology, Physics 79(4): 1048-1054, 2011

No impact of breast magnetic resonance imaging on 15-year outcomes in patients with ductal carcinoma in situ or early-stage invasive breast cancer managed with breast conservation therapy. Cancer 123(8): 1324-1332, 2016

The impact of Her2/neu status on local recurrence in women with stage I-II breast cancer treated with breast conservation therapy. International Journal of Radiation Oncology*biology*physics 60: S135-S135, 2004

The role of radiotherapy in elderly women with early-stage breast cancer treated with breast conserving surgery. Tumori 2018: 300891618792465, 2018

Local recurrence and survival among black women with early-stage breast cancer treated with breast-conservation therapy or mastectomy. Annals of Surgical Oncology 6(3): 241-248, 1999

An assessment of treatment options for breast conservation in the elderly woman with early stage breast cancer. International Journal of Radiation Oncology, Biology, Physics 31(4): 1015-1017, 1995

History of prior pregnancy confers better prognosis in older women with early stage breast cancer treated with breast conservation therapy. International Journal of Radiation Oncology Biology Physics 54(2 Supplement): 91, 2002

Breast irradiation in women with early stage invasive breast cancer following breast conservation surgery. Provincial Breast Disease Site Group. Cancer Prevention and Control 1(3): 228-240, 1997

21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery. Frontiers in Oncology 9: 1, 2019

Long-term Outcomes and Clinicopathologic Differences of African-American Versus White Patients Treated With Breast Conservation Therapy for Early-stage Breast Cancer. Breast Diseases: A Year Book Quarterly 20(2): 146-147, 2009

Long-term outcomes and clinicopathologic differences of African-American versus white patients treated with breast conservation therapy for early-stage breast cancer. Cancer 113(9): 2565-2574, 2008

The impact of re-excision and residual disease on local recurrence after breast conservation treatment for patients with early stage breast cancer. Clinical Breast Cancer 11(6): 400-405, 2012

Clinical outcomes of prospectively treated 140 women with early stage breast cancer using accelerated partial breast irradiation with 3 dimensional computerized tomography based brachytherapy. RadioTherapy and Oncology 115(3): 349-354, 2015

Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. European Journal of Cancer 46(18): 3219-3232, 2011