EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)


The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)



Toxicon: Official Journal of the International Society on Toxinology 50(8): 1041-1052



ISSN/ISBN: 0041-0101

PMID: 17904179

DOI: 10.1016/j.toxicon.2007.07.023

The Snake Venom Detection Kit (SVDK) is of major medical importance in Australia, yet it has never been rigorously characterised in terms of its sensitivity and specificity, especially when it comes to reports of false-negative and false-positive results. This study investigates reactions and cross-reactions of five venoms the SVDK is directed against and a number of purified toxins. Snakes showing the closest evolutionary relationships demonstrated the lowest level of cross-reactivity between groups. This was, instead, far more evident between snakes that are extraordinarily evolutionary separated. These snakes: Pseudechis australis, Acanthophis antarcticus and Notechis scutatus, in fact displayed more false-positive results. Examination of individual toxin groups showed that phospholipase A(2)s (PLA(2)s) tends to react strongly and display considerable cross-reactivity across groups while the three-finger toxins (3FTx) reacted poorly in all but the Acanthophis well. The hook effect was evident for all venoms, particularly Oxyuranus scutellatus. The results of this study show considerable variation in toxin detection, with implications in further development of venom detection, both in Australia and other countries.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 021956124

Download citation: RISBibTeXText

Related references

Haemolysis by Australian Snake Venoms. 1. The comparative haemolytic power of Australian snake venom. 2. Some peculiarities in the behaviour of the Haemolysis of Australian snake venom. Australian Journal of Experimental Biology and Medical Science 112: 75-94, 1933

Bothrops fonsecai snake venom activities and cross-reactivity with commercial bothropic venom. Comparative Biochemistry and Physiology. Toxicology and Pharmacology: Cbp 191: 86-100, 2017

Allergens in Hymenoptera venom XV: the immunologic basis of vespid venom cross-reactivity. Journal of Allergy and Clinical Immunology 75(5): 611-613, 1985

Cross reactivity of snake venom antisera. Toxicon 23(4): 624, 1985

Cross reactivity between venomous, mildly venomous, and non-venomous snake venoms with the Commonwealth Serum Laboratories Venom Detection Kit. Emergency Medicine Australasia: Ema 16(5-6): 459-464, 2004

Studies on the cross-reactivity of snake venom antisera. Memorias do Instituto Butantan (Sao Paulo 51(4): 127-132, 1990

Studies on the cross reactivity of snake venom antisera. Memorias do Instituto Butantan (Sao Paulo) 51(4): 127-132, 1989

Snake venom components and their cross-reactivity: a review. Biochemistry and Cell Biology 67(9): 597-601, 1989

Cross-reactivity of bardick snake venom with death adder antivenom. Medical Journal of Australia 140(9): 541-542, 1984

Snake venom hemorrhagins cross reactivity in neutralization by commercial antivenoms. Toxicon 26(1): 32, 1988

Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?. Toxicon: Official Journal of the International Society on Toxinology 50(2): 206-213, 2007

Assessment of quality, safety, and pre-clinical toxicity of an equine polyvalent anti-snake venom (Pan Africa): Determination of immunological cross-reactivity of antivenom against venom samples of Elapidae and Viperidae snakes of Africa. Toxicon: Official Journal of the International Society on Toxinology 153: 120-127, 2018

Haemolysis by Australian snake venoms. I. The comparative haemolytic power of Australian snake venoms. II. Some peculiarities in the behavior of the haemolysis of Australian snake venom. Australian Jour Exp Biol And Med Sci 11(2): 75-80, 81-94, 1933

Micrurus snake species: Venom immunogenicity, antiserum cross-reactivity and neutralization potential. Toxicon: Official Journal of the International Society on Toxinology 117: 59-68, 2016

Molecular diversity in venom from the Australian Brown snake, Pseudonaja textilis. Molecular and Cellular Proteomics: Mcp 5(2): 379-389, 2006