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Zymocin, a composite chitinase and tRNase killer toxin from yeast

Zymocin, a composite chitinase and tRNase killer toxin from yeast

Biochemical Society Transactions 35(Pt 6): 1533-1537

Growth inhibition of Saccharomyces cerevisiae by the plasmid-encoded trimeric (alphabetagamma) zymocin toxin from dairy yeast, Kluyveromyces lactis, depends on a multistep response pathway in budding yeast. Following early processes that mediate cell-surface contact by the chitinase alpha-subunit of zymocin, later steps enable import of the gamma-toxin tRNase subunit and cleavage of target tRNAs that carry modified U34 (wobble uridine) bases. With the emergence of zymocin-like toxins, continued zymocin research is expected to yield new insights into the evolution of yeast pathosystems and their lethal modes of action.

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Accession: 022130290

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PMID: 18031261

DOI: 10.1042/BST0351533

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