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12-nt insertion in 3' untranslated region leads to attenuation of classic swine fever virus and protects host against lethal challenge

12-nt insertion in 3' untranslated region leads to attenuation of classic swine fever virus and protects host against lethal challenge

Virology 374(2): 390-398

We report here the discovery of an attenuation mechanism of classic swine fever virus (CSFV) induced by introduction of a continuous 12-nt (CUUUUUUCUUUU) insertion in viral 3' UTR. The 12-nt insertion sequence was first found in one attenuated vaccine strain HCLV (Hog Cholera Lapinized Virus) which did not exist in other CSFV strains.

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Accession: 022130935

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PMID: 18279903

DOI: 10.1016/j.virol.2008.01.008

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