+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

DeconMSn: a software tool for accurate parent ion monoisotopic mass determination for tandem mass spectra



DeconMSn: a software tool for accurate parent ion monoisotopic mass determination for tandem mass spectra



Bioinformatics 24(7): 1021-1023



DeconMSn accurately determines the monoisotopic mass and charge state of parent ions from high-resolution tandem mass spectrometry data, offering significant improvement for LTQ_FT and LTQ_Orbitrap instruments over the commercially delivered Thermo Fisher Scientific's extract_msn tool. Optimal parent ion mass tolerance values can be determined using accurate mass information, thus improving peptide identifications for high-mass measurement accuracy experiments. For low-resolution data from LCQ and LTQ instruments, DeconMSn incorporates a support-vector-machine-based charge detection algorithm that identifies the most likely charge of a parent species through peak characteristics of its fragmentation pattern. http://ncrr.pnl.gov/software/ or http://www.proteomicsresource.org/.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 022332718

Download citation: RISBibTeXText

PMID: 18304935

DOI: 10.1093/bioinformatics/btn063


Related references

DtaRefinery, a software tool for elimination of systematic errors from parent ion mass measurements in tandem mass spectra data sets. Molecular and Cellular Proteomics 9(3): 486-496, 2010

Determination of accurate protein monoisotopic mass with the most abundant mass measurable using high-resolution mass spectrometry. Analytical Biochemistry 440(1): 108-113, 2013

PParse: a method for accurate determination of monoisotopic peaks in high-resolution mass spectra. Proteomics 12(2): 226-235, 2012

Multiplexed Post-Experimental Monoisotopic Mass Refinement (mPE-MMR) to Increase Sensitivity and Accuracy in Peptide Identifications from Tandem Mass Spectra of Cofragmentation. Analytical Chemistry 89(2): 1244-1253, 2017

Integrated post-experiment monoisotopic mass refinement: an integrated approach to accurately assign monoisotopic precursor masses to tandem mass spectrometric data. Analytical Chemistry 82(20): 8510-8518, 2010

MS2Analyzer: A software for small molecule substructure annotations from accurate tandem mass spectra. Analytical Chemistry 86(21): 10724-10731, 2014

Electron ionization mass spectra of bis-1,2,4-oxadiazoles: tandem mass spectrometry and accurate mass measurements. Rapid Communications in Mass Spectrometry 15(11): 884-888, 2001

MMass as a software tool for the annotation of cyclic peptide tandem mass spectra. Plos one 7(9): E44913, 2012

Identification of the 'wrong' active pharmaceutical ingredient in a counterfeit Halfan drug product using accurate mass electrospray ionisation mass spectrometry, accurate mass tandem mass spectrometry and liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 17(3): 215-221, 2003

Postexperiment monoisotopic mass filtering and refinement (PE-MMR) of tandem mass spectrometric data increases accuracy of peptide identification in LC/MS/MS. Molecular and Cellular Proteomics 7(6): 1124-1134, 2008

Accurate monoisotopic mass measurements of peptides Possibilities and limitations of high resolution time-of-flight particle desorption mass spectrometry. Rapid Communications in Mass Spectrometry 10(11): 1386-1392, 1996

Accurate mass determination of short-lived isotopes by a tandem Penning-trap mass spectrometer. Physical Review Letters 65(25): 3104-3107, 1990

Patchwork peptide sequencing: extraction of sequence information from accurate mass data of peptide tandem mass spectra recorded at high resolution. Proteomics 2(5): 524-533, 2002

Determination of monoisotopic masses of chimera spectra from high-resolution mass spectrometric data by use of isotopic peak intensity ratio modeling. Rapid Communications in Mass Spectrometry 26(16): 1875-1886, 2012

Interpretation of oligonucleotide mass spectra for determination of sequence using electrospray ionization and tandem mass spectrometry. Analytical Chemistry 68(13): 1989-1999, 1996