Effects of Salvinorin A on Locomotor Sensitization to D2/D3 Dopamine Agonist Quinpirole
Beerepoot, P.; Lam, V.; Luu, A.; Tsoi, B.; Siebert, D.; Szechtman, H.
Neuroscience Letters 446(2-3): 101-104
ISSN/ISBN: 0304-3940 PMID: 18824069 DOI: 10.1016/j.neulet.2008.09.035
Locomotor sensitization induced by the dopamine agonist quinpirole can be potentiated by co-treatment with the synthetic kappa opioid agonist U69593. The identification of salvinorin A, an active component of the psychotropic sage Salvia divinorum, as a structurally different agonist of kappa-opioid receptors raised the question of whether this compound would similarly potentiate sensitization to quinpirole.