Section 23
Chapter 22,504

Effects of Salvinorin A on Locomotor Sensitization to D2/D3 Dopamine Agonist Quinpirole

Beerepoot, P.; Lam, V.; Luu, A.; Tsoi, B.; Siebert, D.; Szechtman, H.

Neuroscience Letters 446(2-3): 101-104


ISSN/ISBN: 0304-3940
PMID: 18824069
DOI: 10.1016/j.neulet.2008.09.035
Accession: 022503291

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Locomotor sensitization induced by the dopamine agonist quinpirole can be potentiated by co-treatment with the synthetic kappa opioid agonist U69593. The identification of salvinorin A, an active component of the psychotropic sage Salvia divinorum, as a structurally different agonist of kappa-opioid receptors raised the question of whether this compound would similarly potentiate sensitization to quinpirole.

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