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Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeast

Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeast

Genes & Development 22(8): 1069-1081

During transcription termination by RNA polymerase II on protein-coding genes, the nuclear 5' exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the polyadenylation site and "torpedoes" the polymerase. We report that the activity of Rat1 is also required for efficient termination by RNA polymerase I (Pol I) on the rDNA.

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Accession: 022522245

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PMID: 18413717

DOI: 10.1101/gad.463708

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