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Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo


Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo



Cellular and Molecular Life Sciences: Cmls 65(20): 3312-3324



ISSN/ISBN: 1420-682X

PMID: 18791851

DOI: 10.1007/s00018-008-8246-4

Cardiac myocytes are the first cells to differentiate during the development of a vertebrate embryo. A wide variety of molecules take part in various steps in this process. While exploring biologically active molecules from marine sources, we found that a constituent of perivitelline fluid from embryos of the Indian horseshoe crab can enhance growth and differentiation of chick embryonic heart. We have purified the factor and identified the cardiac promoting molecule to be a novel lectin.

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Accession: 022557426

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