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Mdm2 promotes genetic instability and transformation independent of p53

Mdm2 promotes genetic instability and transformation independent of p53

Molecular and Cellular Biology 28(15): 4862-4874

Mdm2, a regulator of the tumor suppressor p53, is frequently overexpressed in human malignancies. Mdm2 also has unresolved, p53-independent functions that contribute to tumorigenesis. Here, we show that increased Mdm2 expression induced chromosome/chromatid breaks and delayed DNA double-strand break repair in cells lacking p53 but not in cells with a mutant form of Nbs1, a component of the Mre11/Rad50/Nbs1 DNA repair complex. A 31-amino-acid region of Mdm2 was necessary for binding to Nbs1.

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Accession: 023011713

Download citation: RISBibTeXText

PMID: 18541670

DOI: 10.1128/MCB.01584-07

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