+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Mean time to resolution of gene duplication



Mean time to resolution of gene duplication



Genetica 136(1): 119-126



The mean time to resolution of gene duplication (T(r)) is studied in this paper under the double null recessive (DNR) and haplo-insufficient (HI) models within the same analytical and simulation framework. We show that when population size is not too small (more precisely Nmu > 0.1), T(r) for unlinked duplication is usually larger than that for linked and T(r) for unlinked duplication under the HI model might be greatly prolonged, which were consistent with previous observations. Furthermore, by analytical approach we here indicate the primary underlying mechanism is that the frequency of the original (or wild-type) chromosomal haplotype of the linked duplication decreases nearly exponential to zero with time while that of the unlinked decreases quickly to an quasi-equilibrium; and this phenomenon is particularly profound under the HI model, because the quasi-equilibrium frequency of the original chromosomal haplotype (x(0)) under the HI model is higher than that under the DNR model. These results suggest that recombination and HI model might jointly contribute to the marked prolongation of T(r) even in a modest population. The prolonged T(r) and higher quasi-equilibrium frequency of the original allele at both duplicated loci might have offered more opportunities for the emergence of novel genes.

(PDF emailed within 0-6 h: $19.90)

Accession: 023011870

Download citation: RISBibTeXText

PMID: 18773302

DOI: 10.1007/s10709-008-9319-x


Related references

The resolution of sexual antagonism by gene duplication. Genetics 187(3): 919-937, 2011

Evidence for short-time divergence and long-time conservation of tissue-specific expression after gene duplication. Briefings in Bioinformatics 12(5): 442-448, 2012

Tandem duplication of the NF1 gene detected by high-resolution FISH in 17q112 region. European Journal of Human Genetics 10(Supplement 1): 142, 2002

Tandem duplication of the NF1 gene detected by high-resolution FISH in the 17q11.2 region. Human Genetics 110(4): 314-321, 2002

Time for acquiring a new gene by duplication. Proceedings of the National Academy of Sciences of the United States of America 85(10): 3509-3512, 1988

Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: resolution of AmpliChip CYP450 test no-calls. Pharmacogenomics 12(11): 1617-1622, 2012

Time for spreading of compensatory mutations under gene duplication. Genetics 123(3): 579-584, 1989

Quantitative real-time PCR with SYBR Green detection to assess gene duplication in insects: study of gene dosage in Drosophila melanogaster (Diptera) and in Ostrinia nubilalis (Lepidoptera). Bmc Research Notes 4(): 84-84, 2011

Crystal structure of a conger eel galectin (congerin II) at 1.45 A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication. Journal of Molecular Biology 321(5): 9-89, 2002

Linear-time algorithms for the multiple gene duplication problems. Ieee/Acm Transactions on Computational Biology and Bioinformatics 8(1): 260-265, 2011

Detecting shifts in gene regulatory networks during time-course experiments at single-time-point temporal resolution. Journal of Bioinformatics and Computational Biology 13(5): 1543002-1543002, 2016

The gene-duplication problem: near-linear time algorithms for NNI-based local searches. Ieee/Acm Transactions on Computational Biology and Bioinformatics 6(2): 221-231, 2009

Accelerated evolution after gene duplication: a time-dependent process affecting just one copy. Molecular Biology and Evolution 30(8): 1830-1842, 2014