+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Monosubstituted positively charged cyclodextrins: Synthesis and applications in chiral separation



Monosubstituted positively charged cyclodextrins: Synthesis and applications in chiral separation



Journal of Separation Science 31(18): 3246-3256



Several series of novel structurally well-defined positively charged CDs, applicable to alpha-, beta- and gamma-CDs for chiral separation using CE and chromatographic techniques have been developed. The chiral resolution capabilities of different series CDs towards amino acids and anionic analytes in CE are systematically investigated by considering all separation parameters including CD type, alkyl chain length of the cations attached to the CD rim, CD concentration, buffer pH, separation temperature and organic solvent. Typical results are demonstrated in the context. Examples of chiral separation with HPLC and supercritical fluid chromatography are first demonstrated by using coated chiral stationary phases (CSPs). Optimum CD loading content on the coated CSPs was explored in the chiral separation of neutral analytes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 023063866

Download citation: RISBibTeXText

PMID: 18763252

DOI: 10.1002/jssc.200800357


Related references

Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis. Official Gazette of the United States Patent & Trademark Office Patents 1252(2), 2001

Chiral separation of fluoxetine and its analogs with charged cyclodextrins by capillary electrophoresis. Journal of Liquid Chromatography & Related Technologies 26(14): 2351-2367, 2003

A family of single-isomer positively charged cyclodextrins as chiral selectors for capillary electrophoresis: mono-6A-butylammonium-6A-deoxy-beta-cyclodextrin tosylate. Electrophoresis 26(16): 3125-3133, 2005

Comparison of native, alkylated and charged cyclodextrins for the chiral separation of labetalol stereoisomers by capillary electrophoresis. Journal of Chromatography A 829(1-2): 341-349, 1998

Enantiomeric separation of chiral peptide nucleic acid monomers by capillary electrophoresis with charged cyclodextrins. Electrophoresis 24(15): 2698-2703, 2003

Enantiomeric separation of acidic drugs by capillary electrophoresis using a combination of charged and uncharged beta-cyclodextrins as chiral selectors. HRC Journal of High Resolution Chromatography 19(12): 669-673, 1996

Comparison of chiral separation of basic drugs in capillary electrophoresis and liquid chromatography using neutral and negatively charged cyclodextrins. AnalyticaChimicaActa645(1-2):98, 2009

Preparation of a positively charged cellulose derivative chiral stationary phase with copolymerization reaction for capillary electrochromatographic separation of enantiomers. Electrophoresis 25(16): 2817-2824, 2004

Capillary electrochromatographic separation of enantiomers on chemically bonded type of cellulose derivative chiral stationary phases with a positively charged spacer. Electrophoresis 24(15): 2559-2566, 2003

A novel positively charged achiral co-monomer for β-cyclodextrin monolithic stationary phase: improved chiral separation of acidic compounds using capillary electrochromatography coupled to mass spectrometry. Journal of Chromatography. a 1267: 144-155, 2012

Inhibition of phosphatase activity by positively-charged cyclodextrins. Organic Letters 1(12): 1945-1948, 1999

Inhibition of Phosphatase Activity by Positively-Charged Cyclodextrins. Organic Letters 1(12): 1945-1948, 1999

Modeling and optimization of the chiral selectivity of basic analytes in chiral capillary electrophoresis with negatively charged cyclodextrins using electrochemical detection. Electrophoresis 22(10): 2025-2031, 2001

Effective synthesis of negatively charged cyclodextrins Selective access to phosphate cyclodextrins. Tetrahedron 64(32): 7587-7593, 2008

Chiral separation of basic drugs using cyclodextrins as chiral pseudo-stationary phases in capillary electrophoresis. Journal of Chromatography 648(1): 267-274, 1993