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Poly(A) leader of eukaryotic mRNA bypasses the dependence of translation on initiation factors

Poly(A) leader of eukaryotic mRNA bypasses the dependence of translation on initiation factors

Proceedings of the National Academy of Sciences of the United States of America 105(31): 10738-10743

Eukaryotic mRNAs in which a poly(A) sequence precedes the initiation codon are known to exhibit a significantly enhanced cap-independent translation, both in vivo and in cell-free translation systems. Consistent with high expression levels of poxviral mRNAs, they contain poly(A) sequences at their 5' ends, immediately before the initiation AUG codon.

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Accession: 023378830

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PMID: 18658239

DOI: 10.1073/pnas.0804940105

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