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Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats



Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats



Journal of Ethnopharmacology 118(2): 318-323



Aim of the study: In African traditional medicine, different parts of Phyllanthus amarus Schum. and Thonn. (family: Euphorbiaceae) are highly valued for the treatment of array of human diseases including hepatic and urolithic and/or other renal diseases. In the present study, single oral 100-400 mg/kg/day of the leaf and seed aqueous extract of Phyllanthus amarus (PA) were studied for their protective effects in acetaminophen- and gentamicin-induced nephrotoxic Wistar rats for 14 days.

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Accession: 023430455

Download citation: RISBibTeXText

PMID: 18554830

DOI: 10.1016/j.jep.2008.04.025


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