Sedentary and migratory states of Schwann cells

Lubinska, L.

Experimental Cell Research Suppl 8: 74-90


ISSN/ISBN: 0014-4827
PMID: 13763943
DOI: 10.1016/0014-4827(61)90341-x
Accession: 023573355

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In a myelinated fiber the Schwann cells are sedentary, maintain a constant form and do not proliferate. Such stability seems to be linked with the presence of myelin. Before myelinization or when the myelin is disrupted, the Schwann cells exhibit plasticity of shape and proliferative and migratory activities, as observed in the embryo, in degenerating nerves and in cultures in vitro. Under all these conditions the behavior of Schwann cells is remarkably similar. Total destruction of myelin is not necessary for release of Schwann cells. Experiments are described in which demyelination of a small part of the internode was accompanied by multiplication of Schwann nuclei and migration of daughter cells along the internode, between neurilemma and preserved myelin, towards the demyelinated region. Some features of axon-Schwann cell relationship are discussed in the light of these experiments.