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Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution



Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution



Proceedings of the National Academy of Sciences of the United States of America 105(26): 9065-9069



The hemagglutinin-esterases (HEs) are a family of viral envelope glycoproteins that mediate reversible attachment to O-acetylated sialic acids by acting both as lectins and as receptor-destroying enzymes (RDEs). Related HEs occur in influenza C, toro-, and coronaviruses, apparently as a result of relatively recent lateral gene transfer events. Here, we report the crystal structure of a coronavirus (CoV) HE in complex with its receptor.

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Accession: 023675990

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PMID: 18550812

DOI: 10.1073/pnas.0800502105


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