Behavioral and Electroencephalographic effects of Lsd
Horovitz, Z.P.; Mulroy, M.I.; Waldron, T.; Leaf, R.
Journal of Pharmaceutical Sciences 54: 108-110
D-Lysergic acid diethylamide tartrate (LSD) was evaluated in cats with permanently implanted electrodes for effects on behavior-eeg correlations and on rates of responding for electrical stimulation to the lateral hypothalamus (self-stimulation) and responding for milk reward. Doses of 10 and 15 mcg./Kg. of LSD intraperitoneally increased responding for lateral hypothalamlc self-stmulation, stimulated observable behavior, and caused a low-voltage fast cortical eeg to predominate. A dose of 25 mcg/Kg, of LSD produced slight decreases in self-stimulation responding. It also caused disorientation, howling, and periodic pacing and staring. This behavior was associated with a change in EEG patterns toward a slow-wave high-voltage response.