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Beta-propiolactone plus ultraviolet irradiated plasma. A clinical evaluation for hepatitis, toxicity and allergy



Beta-propiolactone plus ultraviolet irradiated plasma. A clinical evaluation for hepatitis, toxicity and allergy



Proceedings Congress Int Society Blood Transfus 9: 644-647



The treatment of plasma with beta-propiolactone (BPL) has been studied clinically for a 10 year period: A 4 year study (1951-1956), during which time BPL was used alone as the sterilizing agent, and the present 6 year report (1956-61), during which time the pooled plasma was treated by the combined procedure of beta-protiolactone plus ultraviolet irradiation. In this 10 year period, 995 plasma recipients received a total of 2563 transfusions without evidence of clinical hepatitis, toxicity or allergic reactions proved to be attributable to the treated plasma.

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