Change of the coagulation and anticoagulation system of the blood with complex therapy with anticoagulants of patients with acute and chronic coronary insufficiency
Med Zh Uzb 4: 50-54
In patients with chronic coronary insufficiency before treatment there was observed a reduction in the blood coagulation time and the heparin time, an increase of plasma tolerance to heparin, and a decrease of the fibrinolytic activity of the blood, which indicated a predisposition toward thrombogenesis. In acute coronary insufficiency before treatment there was no substantial change in coagulability, heparin time, and prothrombin index; however, an increase in the plasma tolerance toward heparin and a decrease of the fibrinolytic activity of the blood indicated a worsening of the coagulative and anticoagulative systems of the blood, i.e., danger of thromboembolic complications. As a result of treatment the indexes of the coagulative system improved: heparin time and coagulation time lengthened, the plasma tolerance for heparin and the prothrombin index decreased. The fibrinolytic activity of the blood did not change. Treatment with anticoagulants with breaks and individual dosing and with constant control of the indexes of the coagulative-anticoagulative system did not lead to complications. As a result of treatment with anticoagulants pain in the region of the heart either disappeared or decreased, the state of health and ekg indexes improved, and there were no thromboembolic complications.