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Chemotherapy of Arthritis Induced in Rats by Mycobacterial Adjuvant

Newbould, B.B.

British journal of pharmacology and chemotherapy 21: 127-136

1963

ISSN/ISBN: 0366-0826
PMID: 14066137
DOI: 10.1111/j.1476-5381.1963.tb01508.x
Accession: 024320982
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Arthritis induced in rats by mycobacterial adjuvant has been used for the study of compounds of known value in the treatment of rheumatoid arthritis in man. The development of the arthritic syndrome in treated and control rats was followed by measuring the changes in foot thickness of both hind-feet with a micrometer. This method allowed the effect of anti-inflammatory compounds to be expressed quantitatively. Anti-inflammatory activity was readily observed in certain steroids, pyrazolidines, salicylates and sodium aurothiomalate. Chloroquine and hydroxychloroquine were inactive. The inhibition obtained by daily treatment with the steroid paramethasone disappeared when treatment was withdrawn.

Chemotherapy of Arthritis Induced in Rats by Mycobacterial Adjuvant

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