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Chemotherapy of experimental schistosomiasis mansoni: Distribution of antimony-124 in mice and hamsters after a single dose of sodium-antimony dimercaptosuccinate and antimony dimercaptosuccinic acid



Chemotherapy of experimental schistosomiasis mansoni: Distribution of antimony-124 in mice and hamsters after a single dose of sodium-antimony dimercaptosuccinate and antimony dimercaptosuccinic acid



Ann Trop Med Parasitol 58(4): 439-452



The distribution of antimony in the blood, liver, kidneys and intestinal tract of mice and hamsters was studied over a period of 72 hours following,a.single subcutaneous injection of Sb124-labelled sodium antimony(111) dimercaptosuccinate and antimony111) dimercaptosuccinic acid. Mice were injected with the compounds both dissolved or suspended in water and in olive oil; hamsters received only the sodium salt dissolved in water and the acid suspended in oil. In both species, acid in oil produced higher and longer-lasting antimony levels than Na-salt in water, the difference being more pronounced in mice than in hamsters. Na-salt in oil and acid in water (tested in mice only) behaved in an intermediate manner. Although administered to hamsters in doses 10 times lower than to mice, the antimony levels maintained in hamsters were higher and longer-lasting than in mice. It is concluded that these differences account for the better response of Schistosoma mansoni infections to treatment in hamsters than in mice, and likewise for the previously described greater chemothera-peutic efficacy in both species of the acid in oil than of Na-salt in water.

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Chemotherapy of Experimental Schistosomiasis Mansoni: Distribution of Antimony-124 in Mice and Hamsters after a Single Dose of Sodium Antimony Dimercaptosuccinate and Antimony Dimercaptosuccinic Acid. Annals of Tropical Medicine & Parasitology 58(4): 439-452, 1964

Chemotherapy of experimental schistosomiasis mansoni: 38 distribution of antimony-124 in mice and hamsters after a single dose of sodium antimony dimer-captosuccinate and antimony dimercaptosuccinic acid. Ann. trap. Med. Parasit, 58: 4, 439-452, 1964

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