+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic sodium challenge studies in man



Chronic sodium challenge studies in man



Jour Lab and Clin Medicine 55(3): 362-375



In spite of a fixed sodium chloride intake, daily sodium excretion may vary widely. The sodium balance pattern of larger subjects given proportionately larger sodium loads presents a sinusoidal configuration comprising an alternation of positivity and negativity in spite of a fixed sodium intake. The amplitude of the oscillations of sodium excretion is a linear function of the magnitude of the daily sodium chloride load in the short run in all normal patients. The gastrointestinal absorption of sodium chloride in the amounts given is practically complete; the fecal excretion of sodium is insignificant. The urinary potassium excretion in spite of sodium chloride loading as described is generally constant throughout. Hypothetical interrelationships of the above with current concepts of electrolyte metabolism are discussed. Clinical and physiologic interpretations of single 24 hour urinary sodium excretion data must be made with caution.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 024331958

Download citation: RISBibTeXText


Related references

Chronic sodium chloride challenge studies in man. Journal of Laboratory and Clinical Medicine 55: 362-375, 1960

Chronic studies with sodium saccharin and sodium cyclamate in dogs abstract sweeteners. Toxicology and Applied Pharmacology 12(2): 291, 1968

Renin sodium mechanisms in chronic heart failure response to sodium balance studies. American Heart Association Monograph (91): II-286, 1982

The effects of sodium cromoglycate on antigen inhalation challenge in 2 horses affected with chronic obstructive pulmonary disease. Veterinary Immunology and Immunopathology 1(1): 89-96, 1979

The effects of sodium cromoglycate on antigen inhalation challenge in two horses affected with chronic obstructive pulmonary disease (COPD). Veterinary Immunology and Immunopathology 1(1): 89-95, 1979

Sodium 23 nuclear magnetic resonance studies of red blood cells from chronic hemodialysis patients implications for systemic sodium metabolism. Clinical Research 40(1): 112A, 1992

Effect of nedocromil sodium and sodium cromoglycate on connective tissue and bone marrow derived mast cells acute and chronic studies. European Journal of Respiratory Diseases Suppl 69(147): 196-198, 1986

Long term effect of nedocromil sodium on allergen challenge and histamine challenge in asthmatic patients. Journal of Allergy and Clinical Immunology 95(1 Part 2): 217, 1995

Studies on the sodium azide toxicity. II. Chronic poisoning. 3. Absorption of sodium azide through the skin. Medycyna Pracy 16(3): 187-199, 1965

Incremental build-up food challenge--a new diagnostic approach to evaluate pseudoallergic reactions in chronic urticaria: a pilot study: stepwise food challenge in chronic urticaria. Clinical and Experimental Allergy 39(1): 116-126, 2009

The pig model of chronic paraplegia: a challenge for experimental studies in spinal cord injury. Progress in Neurobiology 97(3): 288-303, 2012

Basic and clinical studies on chronic pain and the diagnosis with drug challenge test. Masui. Japanese Journal of Anesthesiology 49 Suppl: S128, 2000

Science trumps politics: urinary sodium data challenge US dietary sodium guideline. American Journal of Clinical Nutrition 92(5): 1005-1006, 2010

Urinary methy-histamine and LTE in patients affected by chronic urticaria after the challenge with food additive and sham-challenge. Allergy 56(Suppl. 68): 218-219, 2001