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Coagulating and anti-coagulating systems of the blood in patients with rheumatic heart defects and their changes under the influence of anticoagulants



Coagulating and anti-coagulating systems of the blood in patients with rheumatic heart defects and their changes under the influence of anticoagulants



Ter Arkh 39(1): 75-79



Disruption in the coagulating and anticoagulating systems in patients with rheumatic heart disease and cardiac insufficiency existed during treatment with cardiac glucosides, diuretics and salicylates. An increase of blood coagulation and inhibition of activity of the fibrinolytic system were found during the acute phase of rheumatism. These changes in combination with disordered hemodynamics and lesions of the vascular wall typical for this group of patients lead to thromboembolic complications (out of 56 cases prior to treatment thromboembolism was seen in 37). The use of anticoagulants normalizes coagulating factors and anticoagulating systems in the majority of patients.

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