+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Combined Effect Of Carcinogens And Co-Carcinogens On Metabolic Process



Combined Effect Of Carcinogens And Co-Carcinogens On Metabolic Process



Acta - Unio Internationalis Contra Cancrum 20: 909-914



The action of the hepatic carcinogen, DAB, is inhibited by the combined use of a drug which accelerates the metabolic function of the liver and cancer incidence is markedly delayed or decreased. Not only toxic compounds like methyl-cholan-threne and barbital, but according to our earlier studies compounds which have good effect on the metabolism, such as thiamine, ascorbic acid, and glucuronic acid, were found to have also a delaying influence on the cancer incidence. On the other hand when one of two kinds of carcinogens decrease the metabolic function of the liver, their combined use is expected to accelerate cancer incidence additively. Continuous administration of substances which damage the metabolic function, such as DAB and DAS. results in a marked decrease of the metabolites. Consequently, at least in case of DAB, it seems to be difficult to consider that a certain intermediate metabolite of DAB, such as 3 or 4[image]-hydroxy-DAB and their N-demethylated derivatives, is responsible for the production of cancer.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 024354049

Download citation: RISBibTeXText

PMID: 14274751


Related references

Chromosomal effects of carcinogens and non-carcinogens on WI-38 after short term exposures with and without metabolic activation. Mutation Research 46(4): 297-304, 1977

1999 Stokinger Award Lecture. Unifying the standard setting process for carcinogens and non-carcinogens. Applied Occupational and Environmental Hygiene 14(11): 742-747, 1999

Natural carcinogens: early changes in cultured cells induced by carcinogens--pre-screening of carcinogens using cell cultures. Nihon Rinsho. Japanese Journal of Clinical Medicine 30(4): 959-964, 1972

Malignant transformation of cells in vitro by chemical carcinogens and viruses. I. The absence of synergism at a combined action of carcinogens and polyoma virus. Tsitologiia 11(2): 242-247, 1969

International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper No. 15/2. Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition. Mutation Research 186(3): 201-233, 1987

Metabolic activation of DMH 1,2-dimethylhydrazine by colonic microsomes: a process influences by type of dietary fat Carcinogens. 1982

Synergism between orally active carcinogens. IV. Results of simultaneous feeding of 4 carcinogens in rats. Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 257(1): 12-12, 1967

On the nature of non-genotoxic carcinogens. A unified theory including NGCs, co-carcinogens and promoters. Mutation Research 281(4): 245-246, 1992

Synergism among oral carcinogens. II. Results of the simultaneous feeding of bladder carcinogens to dogs. Toxicology and Applied Pharmacology 7(5): 657-659, 1965

The role of hypophysis in rats after injection of carcinogens or transplantation of sarcomas induced by carcinogens. Glasnik: 155-163, 1953

Reactions of ultimate carcinogens with cell membranes: importance of carbamoylation of phosphatidylethanolamine by the carcinogens. Carcinogenesis 9(6): 1085-1090, 1988

Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens. Environmental Health Perspectives 67: 201-282, 1986

Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. Proceedings of the National Academy of Sciences of the United States of America 69(11): 3128-3132, 1972

Exposures to carcinogens and consequences of listing of carcinogens in the Swedish working environment. Regulatory Toxicology and Pharmacology 7(2): 185-199, 1987