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Combined Effect Of Carcinogens And Co-Carcinogens On Metabolic Process

Combined Effect Of Carcinogens And Co-Carcinogens On Metabolic Process

Acta - Unio Internationalis Contra Cancrum 20: 909-914

The action of the hepatic carcinogen, DAB, is inhibited by the combined use of a drug which accelerates the metabolic function of the liver and cancer incidence is markedly delayed or decreased. Not only toxic compounds like methyl-cholan-threne and barbital, but according to our earlier studies compounds which have good effect on the metabolism, such as thiamine, ascorbic acid, and glucuronic acid, were found to have also a delaying influence on the cancer incidence. On the other hand when one of two kinds of carcinogens decrease the metabolic function of the liver, their combined use is expected to accelerate cancer incidence additively. Continuous administration of substances which damage the metabolic function, such as DAB and DAS. results in a marked decrease of the metabolites. Consequently, at least in case of DAB, it seems to be difficult to consider that a certain intermediate metabolite of DAB, such as 3 or 4[image]-hydroxy-DAB and their N-demethylated derivatives, is responsible for the production of cancer.

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Accession: 024354049

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PMID: 14274751

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