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Comments on the activity of some constitutents of Withania somnifera Dun. I. The antibacterial activity of five nitrogen-free substances isolated from the leaves

Comments on the activity of some constitutents of Withania somnifera Dun. I. The antibacterial activity of five nitrogen-free substances isolated from the leaves

Antibiotics and ChemoTherapy 12: 576-582

ISSN/ISBN: 0570-3123

PMID: 13867009

The isolation of 5 crystalline substances (A1, A2, A3, A4, and A5) from the leaves of W. somnifera is described. Their antibacterial spectra were investigated. A1, A2, A3, and (to a lesser extent) A4 and A5 were effective against aerobic bacilli. A1 and A2 had also a bacteriostatic effect on strains of Staphylococcus aureus. None of these substances was active against Gram-negative bacteria and anaerobic bacilli.

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