+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of long-term effects of saluretics and of anabolic steroids on renal functions



Comparison of long-term effects of saluretics and of anabolic steroids on renal functions



International symposium on antihypertensive therapy: Principles and practice, 28 June-3 July, 1965, Siena, Italy 448-467



In a group of 20 elderly hypertensive and normotensive residents of a Home for the Aged, renal functions were studied before and after three to 6 mo. of therapy with 50 mg hydrochlorothiazide daily. These subjects had renal plasma flows (KPF) averaging 60% and glomerular filtration rates (GFR) averaging 70% of those of middle-aged persons. Blood pressure was reduced in all subjects, including the few normotensives who completed the period of treatment. At the end of treatment, CIn and CpAH were significantly decreased to means of 83.4% and 86.1% of the respective control vaues, while Tm PAH decreased[long dash]though not significantly -to 90.5%. A moderate hypopotassaemia developed in all subjects, but no significant correlation between it and the decrease in CIn. or CPAH was present. Tubular functional mass changes were quite unrelated to changes in serum potassium. Since the average reduction in mean blood pressure (-15.3%) equalled that of renal plasma flow, whereas total renal resistance was not consistently reduced (-7.8%), decrease in vascular resistance must have occurred in beds other than the renal. Diametrically opposite renal functional responses were obtained by administration of 150 mg methandrostenolone or nandrolone phenylpropionate over a 6-week period to 12 subjects, two of whom were simultaneously receiving hydrochlorothiazide. Significant increases in GFR and Tm PAH were observed; RPF and renal resistance increased and decreased respectively, but these changes were not significant. Anabolic treatment did not affect blood pressures or the serum levels of sodium and potassium. The possibility that anabolic steroids could be used in long-term saluretic therapy to forestall renal functional impairment might be worthy of clinical trial.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 024367973

Download citation: RISBibTeXText


Related references

Long-term effects of anabolic steroids on renal functions in the aged subject. Journal of Gerontology 22(3): 268-273, 1967

Long-term cardiovascular effects of anabolic steroids. Lancet 352(9121): 33, 1998

Effects of anabolic steroids in chronic renal failure. I. Short-term effects. Archives of Internal Medicine 120(4): 408-416, 1967

Effects of anabolic steroids in the long-term treatment of ischaemic leg ulcers. Zentralblatt für Phlebologie 7(3): 248-256, 1968

Effects of long term supplementation of anabolic androgen steroids on human skeletal muscle. Plos one 9(9): E105330, 2014

Case report: The long-term effects of anabolic steroids on the female voice over a 20-year period. Clinical Case Reports 7(5): 1067-1070, 2019

Epidemiological and policy issues in the measurement of the long term health effects of anabolic-androgenic steroids. Sports Medicine 8(3): 129-138, 1989

Anabolic steroids: Lots of muscle in the short-term, potentially devastating health consequences in the long-term. Drug and Alcohol Review 35(4): 375-376, 2016

Long-Term Treatment of Osteoporosis with Anabolic Steroids. Deutsche Medizinische Wochenschrift 90: 386-390, 1965

Adverse effects of anabolic steroids on reproductive functions of mares. Equine Veterinary Data 3(21): 326-328, 1982

Long term therapy of liver cirrhosis with anabolic steroids. Medizinische Klinik 62(2): 59-63, 1967

Liver lesions due to long-term use of anabolic steroids or oral contraceptives. Nederlands Tijdschrift Voor Geneeskunde 120(50): 2224-2225, 1976

Liver lesions due to long-term use of anabolic steroids and oral contraceptives. Nederlands Tijdschrift Voor Geneeskunde 120(50): 2214-2220, 1976

On the therapeutic effect of long-term anabolic steroids for fattening calves. Tierarztliche Umschau: 24 (1) 41-42, 1969

Clinical investigations on long-term activation of fibrinolysis by anabolic steroids. Folia Haematologica 113(1-2): 223-229, 1986