Contribute allo studio della patogenesi della tu-bercolosi gastrica

Torchiana, L.; Andrei, O.

Ann Ital Chir 6(5): 424-449

1928


Accession: 024390887

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Abstract
The authors, after elucidating the reasons for the rarity of gastric localization of tuberculosis by references to various writers on the defensive action of the gastric juice, the presence and function of submucous lymphatic follicles and on the association of various chemical and physical factors of defense, consider the various possible ways through which infection could reach the stomach. Experimentally, they try to solve the problem by experiments on dogs, rabbits and guinea pigs. They obtained no gastric localization of the disease by: feeding the animals bacterial cultures and altering the gastric acidity with alkalies; producing traumatic lesions of the mucosa; traumatizing the stomach or injecting germs into the general circulation; in addition to the above, resection of the left venticle; and lowering the antipeptic power of the blood by injections of pyrodine, pressing the gastric wall and injecting germs into the circulation. Only by injecting bacterial suspensions into the arteries of the stomach, or directly into the walls, could lesions be obtained, but they differed from those seen in man, being multiple, small localizations affecting sometimes a tunica only and tending to recovery, while in other organs infection developed abundantly and progressively. The authors never observed ulcerative forms. The difficulty of infecting the stomach with tuberculosis is attributed to mechanical factors, secretions, and to immunity, local and specific, based on a special chemical constitution of the tissue. This immunity is specially characteristic of the mucosa.