Developmental studies on emetic response to tartar emetic and copper sulfate in the cat

Brizzee, K.R.; Marshall, K.R.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 103: 839-842

1960


ISSN/ISBN: 0037-9727
PMID: 13804527
Accession: 024473958

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Abstract
Incidence of vomiting to copper sulfate (8 mg/kg and 80 mg/kg in 1% solution) and tartar emetic (5 mg/kg and 50 mg/kg in 1% solution) increased significantly as shown by chi square tests, from animals weighing 150 g or less to a group weighing 200 g or more. A significant increase in incidence was also noted between animals (200 g or over) tested with low and high doses of these 2 drugs. While incidence increased to higher dose levels in the latter group, no significant increase in incidence to the higher dose levels was found in the young group (150 g or less). The period between 150 g and 200 g apparently is critical in development of emetic response to copper sulfate and tartar emetic. The emetic act in older animals is more vigorous than in younger groups but the sequential chain of events leading to vomiting is similar.