Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice
Renoir, T.; Païzanis, E.; El Yacoubi, M.; Saurini, Fçoise.; Hanoun, Nïma.; Melfort, M.; Lesch, K.Peter.; Hamon, M.; Lanfumey, L.
International Journal of Neuropsychopharmacology 11(8): 1149-1162
Although numerous studies investigated the mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity, little is known about its long-term functional consequences on 5-HT neurotransmission in mice. This led us to evaluate the delayed effects of MDMA exposure on the 5-HT system, using in-vitro and in-vivo approaches in both 5-HTT wild-type and knock-out mice.