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Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice

Renoir, T.; Païzanis, E.; El Yacoubi, M.; Saurini, Fçoise.; Hanoun, Nïma.; Melfort, M.; Lesch, K.Peter.; Hamon, M.; Lanfumey, L.

International Journal of Neuropsychopharmacology 11(8): 1149-1162

2008

ISSN/ISBN: 1461-1457
PMID: 18611291
DOI: 10.1017/s1461145708009048
Accession: 024490824
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Although numerous studies investigated the mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity, little is known about its long-term functional consequences on 5-HT neurotransmission in mice. This led us to evaluate the delayed effects of MDMA exposure on the 5-HT system, using in-vitro and in-vivo approaches in both 5-HTT wild-type and knock-out mice.

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