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Dimethyl sulfoxide Its steroid solubility and endo-crinologic and pharmacologic-toxicologic characteristics



Dimethyl sulfoxide Its steroid solubility and endo-crinologic and pharmacologic-toxicologic characteristics



Cancer Chemother Repts: 24



Dimethyl sulfoxide was investigated for its usefulness as a general solvent for screening programs. Excellent solubility was obtained for 16 steroid and non-steroid compounds, some of which could not be properly handled in the steroid-suspending vehicle (SSV). Assays that were done simultaneously to compare the usual vehicle with dimethyl sulfoxide included andro-genic, uterotrophic, progestational, glycogenic, anti-inflammatory, thymolytic, antiadrenal, and antipituitary.

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