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Donnees experimen-tales et pratiques sur les proprietes anthelminthiques de la phenothiazine , et de ses derives



Donnees experimen-tales et pratiques sur les proprietes anthelminthiques de la phenothiazine , et de ses derives



Bull Soc Path Exot 38(9/10): 288-299



Rhabditis macrocerca was killed in less than 1 day by 1-500 phenothiazine in water. Aspicularis tetraptera was eliminated from mice by 0.08 g. phenothiazine daily for 8 days by mouth, but toxic symptoms were observed. Treatment for a shorter time was not satisfactory. Passalurus ambiguus was eliminated from 2 rabbits by 5 daily oral doses of 0.1 g. phenothiazine per kg. body weight. R. macrocerca was killed in less than a day by 1-500 N-methyphenothiazine, N-ethylphenothiazine, tetrachlorophenothia-zine, methylene blue or thionol. It was killed in less than 3 days by 1-500 thionine. A. tetraptera in mice was not affected by 0.1 g. per kg. methylene blue or thionol daily for 8 days; this regimen of thionine had some effect. Higher doses of methylene blue and thionine were toxic for the mice. The ratio of curative to toxic dose of phenothiazine in the mouse is 1:1, while in the rabbit it is 1:10, and in man 1:4.

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