Dopaminergic activation excites rat lateral habenular neurons in vivo
Kowski, A.B.; Veh, R.W.; Weiss, T.
Neuroscience 161(4): 1154-1165
ISSN/ISBN: 0306-4522 PMID: 19374940 DOI: 10.1016/j.neuroscience.2009.04.026
The lateral habenular complex (LHb) of the epithalamus is part of a dorsal diencephalic conduction system connecting basal forebrain with regulatory midbrain nuclei. The LHb has been implicated in the regulation of ascending monoaminergic transmission, particularly midbrain dopaminergic neuronal activity. Here, we have investigated whether the LHb in turn is subject to dopaminergic modulation. Alterations in spontaneous neuronal activity within the LHb following systemic application of dopaminergic drugs have been examined in anesthetized rats using extracellular single unit recordings. The administration of apomorphine (2 mg/kg) resulted in an excitation of individual LHb neurons.