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Early antibody response in mice to either infection or immunization with Salmonella typhimurium


, : Early antibody response in mice to either infection or immunization with Salmonella typhimurium. Journal of Bacteriology 93(3): 773-778

After immunization with either live or heat-killed Salmonella typhimurium, mice responded with an extremely rapid production of bactericidal antibody which was correlated with the appearance of immunity to a heavy challenge dose (100 ld(50)) of the virulent bacteria. Inactivation of sera with mercaptoethanol along with Sephadex fractionation indicated that the observed bactericidal activity was associated with a macroglobulin which was completely mercaptoethanol-sensitive. The unexpected finding, that a heat-killed vaccine gave excellent protection from a challenge dose which killed all unimmunized control mice, seriously challenges the theory attributing immunity against typhoid infection entirely to a cellular host factor produced only in response to a live vaccine.


Accession: 024520918

PMID: 5337833

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Related references

Schlecht S., 1974: Protective immunization with salmonella r mutants against salmonella typhimurium infection in experiments with mice. Zentralblatt fuer Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene Erste Abteilung Originale Reihe A Medizinische Mikrobiologie und Parasitologie 227(1-4): 250-256

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