Effect of hormones upon cells grown in vitro. I. The effect of sex hormones upon fibroblasts. II. The effects of hormones from the thyroid, pancreas and adrenal gland

Von, H.am, E.; Cappel, L.

American Journal of Cancer 39(3): 350-359

1940


Accession: 024546932

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Abstract
I. Fibroblasts from the heart of fetal mice, 19-22 days, were grown in Carrel flasks (D 3.5) or on cover glasses and exposed to various cones, of sex hormones. Estrin 10-7 gave a slightly higher mitotic and greater area gain than greater or less concs. or than the control. Greater concs. inhibited growth. Testosterone and progestin 10-4 to 10-7 inhibited growth. II. Fibroblasts from the heart of fetal mice, 19-22 days, exposed in tissue cul ture to thyroxin 10-7 to 10-9 showed more rapid gain in area and more frequent mitoses than controls. Insulin, 1 unit per cc, proved to be even more effective in promoting growth. Adrenaline, 10-4 to 10-7, and cortin, 10-1 to 10-7, inhibited growth as compared to controls.