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Effect of some biogenic vessel active substances on the capillary permeability rabbit skin for macromolecules


Effect of some biogenic vessel active substances on the capillary permeability rabbit skin for macromolecules



Arch Exptl Pathol U Pharmakol 242(4): 390-402



A method is described which permits measurement of changes in capillary permeability of rabbit skin. After the intracutaneous injection of bradykinin, histamine, acetylcholine, kallikrein, trypsin and chymo-trypsin, the permeability rate for macromolecules (colloidal gold and polyphosphate) increases depending on the concentration of the active substances, while epinephrine, serotonin and hypertensin delay passage. Hyaluronidase showed only slight activity in a similar test. From these results the following working hypothesis was formulated vascular dilating substances increase the permeability rate while vascular constricting substances decrease it. The changes in the rate of permeability is the result of a mechanical enlargement of the pores of the skin capillaries.

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