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Effect of temperature on the heart rate, electrocardiogram and certain myocardial oxidations of the rat



Effect of temperature on the heart rate, electrocardiogram and certain myocardial oxidations of the rat



Circulation Research 6(6): 771-778



With rats as experimental animals, studies were conducted to establish the nature of the in vivo response of the heart to hypothermia and the in vitro metabolic response of certain enzyme systems to various temperatures. In vivo responses as assayed by changes in body temperature, heart rate, and ecg measurements were quite similar to those of larger animals. The only exception insofar as the heart was concerned was the very low incidence of ventricular fibrillation. In the in vitro metabolic studies it was observed in Arrhenius-van't Hoff plots that ventricular hypothermia was associated with a higher temperature-velocity constant below a temperature of 20-21[degree]C than above it. This was characteristic of tricarboxylic-acid cycle substrate oxidations as well as endogenous respiration.

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Accession: 024563856

Download citation: RISBibTeXText

PMID: 13585606

DOI: 10.1161/01.res.6.6.771


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