+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of threonine- induced amino acid imbalance on the distribution of isotope from PL - tryptophan-5-



Effect of threonine- induced amino acid imbalance on the distribution of isotope from PL - tryptophan-5-



Jour Nutrition 77(2): 142-148



Threonine imbalance was induced by feeding rats an amino acid diet containing 0.1% DL-tryptophan, 0.8% DL-threonine and no niacin. The animals ceased to grow in about 3 weeks during which control rats, receiving a 0.6% DL-threonine diet, gained weight. After 3 weeks, each group was divided into 2 groups, each of which received a test meal of the same diet containing either 0.6 or 0.8% DL-threonine and the same amount of tryptophan labeled with C14 in the 5-position. The imbalanced rats continued on the 0.8% level of threonine excreted a smaller percentage of the C14 in the urine than the other groups. The C14 content of the feces was lower in the animals which received 0.6% threonine throughout the experiment. The C14 in the CO2 and the specific activities of liver tryptophan and niacin were not altered by the dietary threonine level. The results demonstrated that animals which did not grow because of high threonine, were able to incorporate tryptophan into liver tryptophan and niacin. Their lack of growth was not the result of excessive oxidation of tryptophan or of wasting it by urinary excretion. The results are discussed in terms of hypotheses presented to account for threonine imbalance.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 024566122

Download citation: RISBibTeXText


Related references

Effect of Threonine-Induced Amino Acid Imbalance on the Distribution of Isotope from Dl-Tryptophan-5-C14. The Journal of Nutrition 77(2): 142-148, 1962

Effect of threonine-induced amino acid imbalance on the distribution of isotope from DL-tryptophan-5-C14. Journal of Nutrition 77: 142-148, 1962

Effect of Threonine-induced Amino Acid Imbalance on the Excretion of Tryptophan Metabolites by the Rat. The Journal of Nutrition 78(1): 101-108, 1962

Effect of threonine-induced amino acid imbalance on the excretion of tryptophan metabolites by the rat. Journal of Nutrition 78: 101-108, 1962

Tryptophan utilization in a threonine-induced amino acid imbalance in weanling rats: plasma amino acid and liver pyridine nucleotide concentrations. J. Nutrition. 91: 429-440, 1967

Tryptophan Utilization in a Threonine-induced Amino Acid Imbalance in Weanling Rats: Plasma amino acid and liver pyridine nucleotide concentrations. The Journal of Nutrition 91(4): 429-440, 1967

Amino acid balance and imbalance. IV. Specificity of threonine in producing an imbalance in diets deficient in niacin and tryptophan. Journal of Nutrition 71: 296-302, 1960

Tryptophan Utilization in a Threonine-induced Amino Acid Imbalance in Weanling Rats: Gain in Weight and Carcass Nitrogen with Two Feeding Methods. The Journal of Nutrition 89(2): 149-157, 1966

Tryptophan utilization in a threonine-induced amino acid imbalance in weanling rats: gain in weight and carcas nitrogen with two feeding methods. J. Nutrition. 89: 149-157, 1966

Effect of feeding method on threonine induced amino acid imbalance. FED Proceedings 22(2 Pt 1): 202, 1963

Amino acid imbalance as related to methionine, isoleucine, threonine and tryptophan requirement of the rat or mouse. Journal of Nutrition 59(3): 353-370, 1956

A study of a possible mechanism of the threonine-induced amino acid imbalance. Journal of Biological Chemistry 198(1): 63-69, 1952

Amino acid acid imbalance and tryptophan-niacin metabolism L Effect of excess leucine on the urinary excertion of tryptophan-niacin metabolites in rats. J Nutr: 100-106, 1965

Amino acid imbalance and tryptophan-niacin metabolism. 1. Effect of excess leucine on the urinary excretion of tryptophan-niacin metabolites in rats. J. Nutrition. 86: 100-106, 1965

Effect of hormones on amino acid imbalance in short term experiments. 1. Effect of insulin and cortisol on threonine limited diets. Nutrition Rep. Internat 3: 101-109, 1971