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Effect of thyroxin and an anterior pituitary extract containing the growth hormone on endochondral ossification



Effect of thyroxin and an anterior pituitary extract containing the growth hormone on endochondral ossification



Arch Path 34(2): 334-357



Subcut. injs. of thyroxin in normal [female] rats over a period of 251 days caused no perceptible increase grossly or histologically in the rate of endochondral ossification in the tibia or the rib. Thyroparathyroidectomy resulted after approx. 330 days in marked dwarfing; histologically the picture of endochondral ossification at autopsy resembled that following hypophysectomy although the changes were not so severe[long dash]decrease in the size of the chondrocytes, deposition of bone along the zone of erosion, very light formation of cancellous bone and marked increase in the fat content of the marrow. Injs. of thyroxin in these rats were followed by a return to the normal in gross and histological appearance. Injs. of thyroxin in thyroparathyroidectom-ized-hypophysectomized [female] rats had no effect in repairing the growth defect in these animals. Injs. of a bovine ant. pituitary extract containing the growth hormone into normal [female] rats for 251 days resulted in a marked increase in body wt. and length. Histologically, endochondral ossification in the tibia and the rib was extremely active, the resultant picture resembling that of a young animal. In thyroparathyroidectomized rats, a similar period of injs. also caused an increase in the rate of endochondral ossification. The balance between cartilage and bone formation that was finally established favored the former. Injs. of both the extract containing the growth hormone and thyroxin in normal [female] rats over a period of 251 days resulted in a greater response in body wt. and length than that obtained with the extract alone. Histologically, endochondral ossification, although active, was more mature in type; i.e., the epiphysial disk was narrower and replacement by bone more active. This difference between the response to the extract alone and the combined hormones was more pronounced in the thyroparathyroidectomized rats. In the thyroparathyroidectomized-hypo-physectomized animals, the combined extract and thyroxin treatments repaired the growth defect in contrast to the result with thyroxin alone.

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