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Effects of BZ 55 and PBI on blood ATP, inorganic phosphorus and capillary-venous blood sugar difference



Effects of BZ 55 and PBI on blood ATP, inorganic phosphorus and capillary-venous blood sugar difference



Tohoku Jour Exptl Med 69(2/3): 131-136



The effects of BZ 55 (carbutamide) and DBI (phenformin) on blood ATP (adenosine triphosphate), blood inorganic phosphorus and capillary-venous (C-V) blood sugar difference were studied in 9 diabetic patients and 8 healthy adults. The oral administration of 1 g of BZ 55 caused a decrease in blood inorganic phosphorus and C-V difference in diabetics as well as in nondiabetics. The blood ATP level, however, was raised by BZ 55 administration in the diabetic group and lowered in the nondiabetic group. The oral administration of 100 mg of DBI usually produced a slight increase in blood ATP and decreases in blood inorganic phosphorus and in C-V difference. There was no statistically significant difference in these changes between the 2 groups.

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