Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in rats
Suenaga, T.; Kaku, M.; Ichitani, Y.
Pharmacology Biochemistry and Behavior 91(1): 91-96
ISSN/ISBN: 0091-3057 PMID: 18639576 DOI: 10.1016/j.pbb.2008.06.015
Brain cannabinoid receptors are abundantly distributed in the hippocampus, however their detailed role in learning and memory remains unclear. This study investigated the role of hippocampal cannabinoid receptors for performing two kinds of working memory tasks. In experiment 1, intrahippocampal infusion of cannabinoid receptor agonist WIN 55,212-2 (1-2 microg/side) dose-dependently disturbed radial maze performance in rats.