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Effects of postirradiation surgical stress, anesthesia, and spleen transplantation on survival of mice



Effects of postirradiation surgical stress, anesthesia, and spleen transplantation on survival of mice



Radiation Research 6(2): 153-166



The influences of postirradiation surgery, anesthesia, and spleen transplants on survival of X-irradiated 10- to 12-week-old male mice of 3 strains were examined. One strain (Euer) was little affected by the various treatments. Survival of the irradiated CF/1 and DBA/1 mice at 550 r, however, was significantly influenced by some of the procedures. Laparotomies and intraperitoneal or subcu-taneous punctures with a No. 13 gauge trocar enhanced survival in the order named, whereas amputations did not. Isologous and homologous baby spleens, partially reduced the beneficial effect of the surgery. Ether anesthesia of very short duration was decidedly deleterious. These treatments had little or no effect on mice exposed to 900 r; all mice died, and only the time distribution of deaths varied slightly. Under similar experimental conditions, CF/1 mice exposed to 700 r [gamma] -radiation (69% survival) were not benefited by the surgery. Ether anesthesia was toxic, but part of this toxicity was reversed by pre-treating the ether so as to destroy peroxides. The additional stress of fighting among Euer mice immediately after exposure to 900 r [gamma] -radiation resulted in a survival reduced from 43% to 23% in the operated group. The time distribution of deaths was only very slightly altered by the various treatments, but in general the medial death times were consistent with the survival data. The same was true of weight changes.

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Accession: 024583162

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PMID: 13420341

DOI: 10.2307/3570596


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