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Effects of prolonged injections of bovine anterior pituitary extract on bone and cartilage of guinea pigs



Effects of prolonged injections of bovine anterior pituitary extract on bone and cartilage of guinea pigs



Arch Path 29(3): 355-367



Prolonged adm. of an acid extract of the ant. lobe of the bovine pituitary exerts a stimulating action on the proliferation and the ossification of cartilage. These effects are similar to those which were noted after adm. of this extract for shorter periods of time. The balance between proliferation and ossification may be disturbed in favor of one or the other of these 2 processes, and this effect may last for some time; it can be restored at later stages, however, and is responsible for the adjustment of skeletal growth. The course of ossification is influenced not only directly by the adm. of the ant. pituitary extract but also indirectly by the occurrence and the severity of local retrogressive processes taking place subsequently to the adm. of the extract.

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Accession: 024583510

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