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Efficacy of adrenal cortical extract and of paredrine in the prevention of experimental shock following venous occlusion of a limb



Efficacy of adrenal cortical extract and of paredrine in the prevention of experimental shock following venous occlusion of a limb



Arner Jour Physiol 138(1): 1-6



Adrenal cortical extract (ACE) is a beneficial therapeutic agent in the treatment of shock following venous occlusion of a limb. ACE shows a definite tendency to reduce the amt. of fluid lost into the edematous limb, an action more striking than that of desoxycortico-sterone acetate (DCA) alone. However, it has a less marked effect on survival than DCA. Paredrine. a vaso-pressor substance, is of no benefit in shock in which the initiating factor is an escape of plasma fluid, since it appears to augment the escape of fluid through capillaries with impaired permeability.

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