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Einfluss der Entfernung der Nebennieren auf die weiblichen Genitalorgane bei Mausen

, : Einfluss der Entfernung der Nebennieren auf die weiblichen Genitalorgane bei Mausen. Endokrinologie 2(1): 19-40

of 107 mice used, 93 were operated on; 14 served as controls. Suprarenals were completely removed in 72; of these, 23% survived in good condition, average survival time 6 days. Cases surviving more than 12 days quickly recovered body weight and lost all symptoms. Mortality in sexually mature animals was 52.8%, compared with 73.3% for the immature. Cases showing regeneration of the suprarenals showed either no symptoms of extirpation or very temporary disturbances. Accessory suprarenals were composed only of cortex. Complete supra-renalectomy caused profound atrophy of the sex organs. Great degeneration of ova and increase of interstitial tissue followed the operation. No new corpora lutea are formed. These changes are present by the 7th day after operation. Atrophy of the uterus involves the mucosa and muscles. The mucosa. is thin and the glands little developed. This atrophy results from the ovarian atrophy, not from the removal of suprarenals. It is difficult to say whether the sex organ changes are due to interference with metabolism or to the lack of specific gland function. The author believes with Novaks that the latter is the cause.

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