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Electron microscopic observations on certain dense bodies in fibroblasts, synovial and endocardial cells

Electron microscopic observations on certain dense bodies in fibroblasts, synovial and endocardial cells

Revue Canadienne de Biologie 25(3): 117-127

Two types of electron-dense, membranebound cytoplasmic structures are described in proliferating fibroblasts (dermis of rabbits), human endocardial cells and rheumatoid synovium (type B cell). The type I bodies (referred to in the literature as "spindle-shaped" or "rod-shaped" body) contained parallel arrays of fibrils. They were numerous in endocardial cells, less often seen in fibroblasts, and only rarely found in type B synovial cells. The type II bodies (referred to previously by us as "larger" microbodies) had a central, often "bubbly" core, surrounded by a less electrondense zone and a limiting membrane. Fusion of single type II bodies resulted in the formation of larger, more complex units. The type II bodies were most numerous in type B synovial cells, less often observed in fibroblasts, and only rarely found in endocardial cells. Transitional forms having some features of each of the types referred to above were also found, but perhaps they represent oblique or longitudinal sections of the type II bodies. The possible nature of these structures with relation to the cellular functions is discussed. The observations were made on tissues fixed in glutaraldehyde and osmic acid, embedded in Maraglas and stained with uranyl acetate followed by lead citrate.

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Accession: 024600655

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PMID: 5970044

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