Section 25
Chapter 24,612

Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes

Recchia, A.Grazia.; Filice, E.; Pellegrino, D.; Dobrina, A.; Cerra, M.Carmela.; Maggiolini, M.

Journal of Molecular and Cellular Cardiology 46(3): 352-359


ISSN/ISBN: 0022-2828
PMID: 19111553
DOI: 10.1016/j.yjmcc.2008.11.017
Accession: 024611987

Endothelin (ET)-1 is a vasoconstrictor involved in cardiovascular diseases. Connective tissue growth factor/CCN2 (CTGF) is a fibrotic mediator overexpressed in human atherosclerotic lesions, myocardial infarction, and hypertension. In different cell types CTGF regulates cell proliferation/apoptosis, migration, and extracellular matrix (ECM) accumulation and plays important roles in angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis.

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