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Estimation of anticholinergic drug effects in mice by antagonism against pilocarpine-induced salvation

Estimation of anticholinergic drug effects in mice by antagonism against pilocarpine-induced salvation

Acta Pharmacol Toxicol 24(2/3): 243-254

A simple, rapid and sensitive method for estimation of anticholinergic drug effects in anesthetized mice is described. K is based on the antagonism of atropine-like drugs against pilocarpine induced salivation. The 50% salivation inhibition doses of atropine sulfate, hyoscine bromide and hyoscine methonitrate were determined and found to be 8.0, 6.0, and 3.0 [mu]g/kg, respectively. Examples of applying the anti-salivation method in mice to the screening of new compounds for anticholinergic activity are given.

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Accession: 024631459

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PMID: 6013093

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