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Experimental diphtheria of the eye in guinea pigs infected with nontoxigenic diphtheria bacilli and moderate diphtheria bacteriophage



Experimental diphtheria of the eye in guinea pigs infected with nontoxigenic diphtheria bacilli and moderate diphtheria bacteriophage



Zh Mikrobiol Epidemiol Immunobiol 43(9): 21-25



By infecting guinea pigs into the conjunctival sac with a moderate Pc-20 bacteriophage and nontoxigenic diphtheria culture (No. 338) a characteristic clinical picture of diphtheria of the eye of moderate severity and a grave form with a fatal outcome was induced. Morphological lesions typical of diphtheria were revealed in all animals. Cultures of diphtheria bacilli, isolated from the eye of sick guinea pigs, were virulent in the first generations. However, they lost their virulence following several transfers. A bacteriophage, identical by cultural properties and range of action to Pc-29 bacteriophage, was isolated from the same cultures for a period of 4 months (period of investigation).

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