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Experimental infections of mice and guinea pigs parenterally and by natural portals of entry. III. Experiments on guinea pigs with B. anthracis, bacillus of hemorrhagic septi-cemia and other pathogenic bacteria

Experimental infections of mice and guinea pigs parenterally and by natural portals of entry. III. Experiments on guinea pigs with B. anthracis, bacillus of hemorrhagic septi-cemia and other pathogenic bacteria

Zeitschr Hyg U Infektionskr 106(2): 281-307

This report is confined to comparative experiments on guinea pigs by subcutaneous, intraperitoneal and intravenous injections of Bacillus anthracis, B. bipolaris septicus (chicken cholera, hemorrhagic septicaemia), B. paratyphosus B (mouse typhoid), B. tuberculosis and pneumococcus; results are correlated with those obtained by rubbing on the skin, feeding and inhalation of these bacteria. A further comparison is made with results on mice reported in the author's 2 preceding papers. He found the guinea pig subcutaneous tissue considerably more susceptible than the circulatory system or peritoneal cavity; the relatively higher resistance of the 2 latter routes is well shown when highly virulent "animalized" anthrax bacilli are used. In mice, infection by the subcutaneous route follows smaller doses of anthrax spores but death is later than when fatal doses have been given by either of the other 2 routes. The guinea pig abdominal cavity is somewhat more susceptible to the bacillus of chicken cholera and B. paratyphosus B (strains isolated from a spontaneous outbreak of infection in guinea pigs) than the other 2 routes. The pneumococcus strain (isolated from a guinea pig epizootic) was of very low infecting power by any route. All 3 routes gave almost the same extreme susceptibility to B. tuberculosis. In testing the natural routes of infection, certain tissues were shown to have special affinity for certain bacteria. The lungs were found highly susceptible to B. tuberculosis, less but still markedly so to anthrax spores and B. bipolaris septicus and very slightly susceptible to pneumococcus and B. paratyphosus B. The skin was very sensitive to B. anthracis and but slightly so to B. bipolaris septicus, while it appeared quite insusceptible to pneumococcus and B. paratyphosus B. The intestinal tract was found little susceptible to any of the bacteria tested. In discussing the portals of entry under natural conditions and under experimental conditions, the author stresses the importance of the predisposing factors which make possible epizootics with such bacteria as pneumococcus, B. bipolaris septicus and B. paratyphosus. The author further points out that although the portal of entry usually influences the character of disease changes, this is not necessarily so.

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