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Experimental studies on the pharmacology of activated charcoal. HI. Adsorption from gastro-intestinal contents. IV. Adsorption of allypropynal in vivo. V. Absorption of sulphanilamide in vivo



Experimental studies on the pharmacology of activated charcoal. HI. Adsorption from gastro-intestinal contents. IV. Adsorption of allypropynal in vivo. V. Absorption of sulphanilamide in vivo



Acta Pharmacol Et Toxicol 4(3/4): 275-284, 379-400



III. Activated charcoal is only able to adsorb about half as much strychnine nitrate, HgCl2, and diethylbarbituric acid from a soln. containing gastric contents as from pure aqueous solns. Duodenal juice reduced the adsorption of diethylbarbituric acid by about 50% and bile by about 30%.[long dash]IV. The author determined the anesthetic oral dose of allypropynal alone and in combination with activated charcoal. From the decrease in narcotic effect noticed when charcoal is given simultaneously with allypropynol, it can be calculated that 1 g. of charcoal in vivo absorbs an average of 633 mg. of allypropynal.[long dash]V. The concn. of sulfanilamide in blood was determined after oral admn. of sulfanilamide and charcoal. The dose of charcoal required in vivo for total adsorption of 1 g. is about 4 g. in dogs and 6 g. in rabbits. No adsorption is found unless charcoal is given within 1 hr. after admn. of sulfanilamide. The power of absorption in vivo is from 50 to 33% of that found in vitro.

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