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Experimental syphilis of mice, rats, and guinea pigs

Experimental syphilis of mice, rats, and guinea pigs

American Journal of Syphilis 16(4): 535-543

Exps. on 16 mice, 8 rats and 6 guinea pigs showed all susceptible to infection (long latent, especially in the inguinal lymphatic glands and spleen) with Srnrochaeta pallida; local lesions were rarely produced. In mice the brain is also quite susceptible to invasion with S. pallida and the infection may remain latent in this organ for long periods. In view of the extreme latency and limited distribution of syphilitic infection in these animals, it would appear that tests for syphilitic infection with them are of no value.

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